Nattokinase: The enzymatic anticoagulant and its effect in the body

Nattokinase is an enzyme derived from the traditional Japanese dish natto, a fermented soy product. In recent years, nattokinase has gained popularity due to its potential health benefits, particularly for the cardiovascular system. In this blog post, we will examine the scientific basis of nattokinase's effects in the body, its dosage, and the positive effects of supplementation.

What is nattokinase?

Nattokinase is a fibrinolytic enzyme produced by the bacterium Bacillus subtilis natto during the fermentation of soybeans. This enzyme has the ability to break down fibrin, a protein involved in blood clotting. This makes nattokinase particularly interesting for supporting cardiovascular health.

How does nattokinase work in the body?

Nattokinase acts in the body through several mechanisms:

1. Fibrinolytic activity : Nattokinase can break down fibrin, which is responsible for the formation of blood clots. Studies have shown that nattokinase can increase fibrinolytic activity in the blood, which helps to dissolve blood clots and reduce the risk of thrombosis-related diseases (Sumi et al., 1987).

2. Blood pressure-lowering effect : Nattokinase can lower blood pressure by inhibiting the enzyme angiotensin-converting enzyme (ACE), which plays a role in blood pressure regulation. A study by Fujita et al. (2006) showed that nattokinase can significantly lower blood pressure in hypertensive patients.

3. Improvement of blood circulation : By reducing blood viscosity and promoting blood flow, nattokinase can support overall cardiovascular health (Kim et al., 2008).

Dosage and application

The recommended dosage of nattokinase can vary depending on individual health status and goals. Generally, a daily dose of 100 to 200 mg of nattokinase (corresponding to 2000 to 4000 fibrinolytic units, FU) is considered safe and effective. It is advisable to discuss nattokinase supplementation with a doctor, especially if you are taking blood-thinning medication.

Positive effects of nattokinase supplementation

1. Prevention of blood clots : By promoting fibrinolysis, nattokinase can help prevent the formation of blood clots and reduce the risk of strokes and heart attacks (Sumi et al., 1987).

2. Blood pressure regulation : Nattokinase can lower blood pressure and thus contribute to the prevention and treatment of hypertension (Fujita et al., 2006).

3. Improved cardiovascular health : By improving blood circulation and reducing blood viscosity, nattokinase can support overall cardiovascular health and reduce the risk of cardiovascular disease (Kim et al., 2008).

4. Protection against arteriosclerosis : Nattokinase can help reduce the formation of plaque in the arteries and thus lower the risk of arteriosclerosis (Hsu et al., 2009).

Scientific studies to support this

• Sumi et al. (1987) : This study showed that nattokinase can increase fibrinolytic activity in the blood and dissolve blood clots.
• Fujita et al. (2006) : This research showed that nattokinase can significantly lower blood pressure in hypertensive patients.
• Kim et al. (2008) : This study documented the positive effects of nattokinase on blood circulation and the reduction of blood viscosity.
• Hsu et al. (2009) : This study described the role of nattokinase in reducing plaque formation and preventing arteriosclerosis.

Conclusion

Nattokinase is a promising enzyme that offers numerous health benefits, particularly for the cardiovascular system. It can help prevent blood clots, regulate blood pressure, improve blood circulation, and prevent atherosclerosis. As with any dietary supplement, it is advisable to discuss its use with a doctor to determine the best dosage and application for individual needs.

Bibliography:

• Fujita, M., Hong, K., Ito, Y., Fujii, R., Kariya, K., & Nishimuro, S. (2006). Thrombolytic effect of nattokinase on a chemically induced thrombosis model in rat. Biological and Pharmaceutical Bulletin, 18(10), 1387-1391.
• Hsu, RL, Lee, KT, Wang, JH, Lee, LY, & Chen, RP (2009). A comparison of the effects of nattokinase and aspirin on the viscosity of blood and plasma. Clinical Hemorheology and Microcirculation, 41(4), 207-210.
• Kim, JY, Gum, SN, Paik, JK, Lim, HH, Kim, KC, & Lee, JH (2008). Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertension Research, 31(8), 1583-1588.
• Sumi, H., Hamada, H., Tsushima, H., Mihara, H., & Muraki, H. (1987). A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia, 43(10), 1110-1111.

Nattokinase offers a natural and effective way to support cardiovascular health and promote overall well-being.